血小板反应蛋白在释放相关聚集过程中的血小板-血小板识别中发挥作用。

Thrombospondin plays a role in platelet-platelet recognition during release-related aggregation.

作者信息

Agam G, Shohat O, Livne A

出版信息

Proc Soc Exp Biol Med. 1984 Dec;177(3):482-6. doi: 10.3181/00379727-177-41976.

DOI:10.3181/00379727-177-41976

Abstract

Fixed platelets, bearing covalently bound fibrinogen, participate passively in aggregation of fresh platelets when the aggregation process is release related (G. Agam and A. Livne, Thromb Haemostasis 51:145-149, 1984). Inhibition of the release by aspirin abolishes the capability of the fresh platelets activated by 10 microM ADP to interact with the fixed platelets. A supernatant fraction from fresh platelets activated by 10 microM ADP (releasate) reconstitutes the interaction. Purified thrombospondin (TSP) replaces the releasate. Moreover, anti-TSP antibodies abolish the reconstituting effect of the releasate. It is concluded that TSP plays a role in the molecular mechanism of platelet-platelet recognition during release-related aggregation.

摘要

带有共价结合纤维蛋白原的固定血小板，在聚集过程与释放相关时，会被动参与新鲜血小板的聚集（G. 阿加姆和A. 利夫内，《血栓与止血》51:145 - 149，1984年）。阿司匹林对释放的抑制作用消除了由10微摩尔/升二磷酸腺苷（ADP）激活的新鲜血小板与固定血小板相互作用的能力。由10微摩尔/升ADP激活的新鲜血小板的上清液部分（释放物）可重建这种相互作用。纯化的血小板反应蛋白（TSP）可替代释放物。此外，抗TSP抗体消除了释放物的重建作用。得出的结论是，TSP在与释放相关的聚集中血小板 - 血小板识别的分子机制中起作用。