Vestergaard P, Schou M
Pharmacopsychiatry. 1984 Nov;17(6):199-201. doi: 10.1055/s-2007-1017438.
Analysis of more than 350 observations of patients who had been under lithium treatment for 6 months to 4 years showed a significant negative correlation between dosage requirements and age; old patients required less lithium than young patients to maintain a particular serum lithium concentration. The decline in dosage requirement with increasing age could be fully accounted for by the age-dependent fall in the glomerular filtration rate and lithium clearance. There was no age-dependent change in tablet compliance, and the duration of exposure to lithium did not influence the dosage requirement.
对350多名接受锂治疗6个月至4年的患者的观察分析表明，剂量需求与年龄之间存在显著的负相关；老年患者维持特定血清锂浓度所需的锂比年轻患者少。随着年龄增长剂量需求的下降完全可以由肾小球滤过率和锂清除率随年龄的下降来解释。片剂依从性没有随年龄变化，锂暴露时间也不影响剂量需求。
