Schou M, Thomsen K, Vestergaard P
Clin Nephrol. 1986 Apr;25(4):207-11.
The lithium clearance (CLi) is a measure of the delivery of fluid from the proximal tubules to the loop of Henle. We determined the correlations between CLi and a number of variables on 350 occasions in 164 physically healthy persons in lithium treatment for manic-depressive illness. CLi was significantly correlated (p less than 0.001) with sex, age, body surface, urine flow, sodium clearance, potassium clearance, serum lithium concentration, and lithium dosage. Correlations with sex, age and body surface lost statistical significance when the renal variables and the surface were divided by creatinine clearance; these correlations are indirect and caused by common correlations with the filtration rate. The findings show that the fractional delivery of fluid from the proximal tubules is independent of sex, age and body surface. Correlations with urine flow, serum lithium, and lithium dosage could be explained by circumstances connected with the lithium treatment. These variables do not seem to affect CLi. It is concluded that factors which should be taken into account if the assessment of lithium clearance values include the creatinine clearance, the sodium clearance, and the potassium clearance.
锂清除率（CLi）是衡量从近端小管到髓袢液体输送情况的指标。我们在164名接受锂盐治疗躁郁症的身体健康者中进行了350次测定，以确定CLi与多个变量之间的相关性。CLi与性别、年龄、体表面积、尿流量、钠清除率、钾清除率、血清锂浓度及锂剂量显著相关（p小于0.001）。当肾变量和体表面积除以肌酐清除率时，与性别、年龄和体表面积的相关性失去统计学意义；这些相关性是间接的，由与滤过率的共同相关性引起。研究结果表明，从近端小管的液体分数输送与性别、年龄和体表面积无关。与尿流量、血清锂及锂剂量的相关性可由锂治疗相关情况解释。这些变量似乎不影响CLi。结论是，如果评估锂清除率值，应考虑的因素包括肌酐清除率、钠清除率和钾清除率。
