Hamm R J, Lyeth B G
Physiol Behav. 1984 Sep;33(3):499-501. doi: 10.1016/0031-9384(84)90176-8.
Nine rats were placed on a restricted food diet for 14 days and nociceptive thresholds were measured by the tail-flick procedure. After 24 hr of food restriction nociceptive thresholds increased. This initial increase in nociceptive threshold was followed by a decrease in pain threshold on the second day of food restriction. Nociceptive thresholds returned to pre-deprivation levels on the remaining 11 days of food restriction. When the rats were given free access to food after 14 days of food restriction, nociceptive thresholds increased 24 hr after the reintroduction of food and decreased during the next 24 hr. Thus, the results of the present experiment demonstrate that both food restriction and a return to free feeding after 14 days of food restriction produced the same biphasic pattern of changes in nociceptive thresholds.
将9只大鼠限制饮食14天，并通过甩尾试验测量伤害性感受阈值。在禁食24小时后，伤害性感受阈值升高。伤害性感受阈值的这种最初升高之后，在禁食的第二天疼痛阈值降低。在禁食的其余11天里，伤害性感受阈值恢复到剥夺前的水平。当大鼠在禁食14天后可以自由进食时，重新喂食24小时后伤害性感受阈值升高，并在接下来的24小时内降低。因此，本实验结果表明，禁食以及禁食14天后恢复自由进食均产生了相同的伤害性感受阈值双相变化模式。
