Siegrist J
Psychother Psychosom. 1984;42(1-4):90-6. doi: 10.1159/000287828.
An approach focusing on the detrimental role of fundamental threats to one's social status for cardiovascular pathology is briefly outlined. Recent findings of epidemiologic studies in humans and experimental studies in monkeys are interpreted in this framework. Results of a large retrospective case-control study on 380 male patients with clinically documented first acute myocardial infarction (AMI), aged 30-55, and matched controls show a significantly higher percentage of subjects experiencing occupational downward mobility, forced occupational change, and recent cut-down in personnel combined with increased work load in the patient group. Finally, first results of an ongoing prospective study on blue-collar workers are presented indicating predictive power of these social stressors for new AMI cases if combined with indicators of a critically lowered coping threshold.
简要概述了一种关注基本威胁对个体社会地位的不利作用与心血管病理关系的研究方法。在这一框架下对人类流行病学研究和猴子实验研究的最新发现进行了解读。一项针对380名年龄在30 - 55岁、有临床记录的首次急性心肌梗死（AMI）男性患者及匹配对照的大型回顾性病例对照研究结果显示，患者组中经历职业地位下降、被迫职业变动、近期人员裁减且工作负荷增加的受试者比例显著更高。最后，展示了一项正在进行的针对蓝领工人的前瞻性研究的初步结果，表明如果这些社会压力源与应对阈值严重降低的指标相结合，对新的AMI病例具有预测能力。
