上腹部交感神经切除术对大鼠胃酸、血清胃泌素及肠道儿茶酚胺的影响。

Effects of upper abdominal sympathectomy on gastric acid, serum gastrin, and catecholamines in the rat gut.

作者信息

Graffner H, Ekelund M, Håkanson R, Oscarson J, Rosengren E, Sundler F

出版信息

Scand J Gastroenterol. 1984 Sep;19(6):711-6.

Abstract

Selective upper abdominal sympathectomy increased basal acid output in rats but was without effect on stimulated acid output, serum gastrin concentration, and gastric mucosal histidine decarboxylase activity. The sympathectomy was verified by fluorescence histochemistry and determination of tissue catecholamines. A drastic reduction in tissue noradrenaline, adrenaline, and dopamine levels occurred after sympathectomy, and fluorescence microscopy showed a complete loss of adrenergic nerve fibers. Vagotomy reduced catecholamine levels in the stomach wall by 50% but did not affect the catecholamine content in the pancreas and small bowel. Surprisingly, combined vagotomy and upper abdominal sympathectomy resulted in lower catecholamine levels than sympathectomy alone in extragastric but not in gastric tissues.

摘要

选择性上腹部交感神经切除术可增加大鼠基础胃酸分泌量，但对刺激胃酸分泌量、血清胃泌素浓度及胃黏膜组氨酸脱羧酶活性无影响。通过荧光组织化学和组织儿茶酚胺测定来证实交感神经切除术。交感神经切除术后，组织去甲肾上腺素、肾上腺素和多巴胺水平急剧降低，荧光显微镜检查显示肾上腺素能神经纤维完全丧失。迷走神经切断术使胃壁中儿茶酚胺水平降低50%，但不影响胰腺和小肠中的儿茶酚胺含量。令人惊讶的是，迷走神经切断术与上腹部交感神经切除术联合应用时，胃外组织中的儿茶酚胺水平低于单独行交感神经切除术时，但胃组织中的儿茶酚胺水平并非如此。