Martsevich S Iu, Shakarova S Sh, Metelitsa V I, Strel'tsov A A, Vygodin V A
Ter Arkh. 1984;56(9):46-50.
Fifteen patients with coronary heart disease and stable angina pectoris of effort were examined for tolerance to the antianginal effect of isosorbide dinitrate (ID) taken permanently. After 6 weeks of treatment with ID in doses selected on an individual basis the antianginal effect evaluated by bicycle ergometry before and after ID intake remained stable. Sixty per cent of the patients showed a decrease in the drug effect, while in 40 per cent of the patients that decrease was moderate (partial ID tolerance) and in 20 per cent considerable (marked ID tolerance). After the drug dose was twice as raised the patients also remained drug tolerant.
对15例冠心病稳定型劳力性心绞痛患者进行了长期服用硝酸异山梨酯（ID）抗心绞痛作用耐受性的检查。根据个体情况选择剂量用ID治疗6周后，通过服药前后的自行车测力计评估的抗心绞痛作用保持稳定。60%的患者出现药物作用降低，其中40%的患者降低程度中等（部分ID耐受性），20%的患者降低程度显著（明显ID耐受性）。在将药物剂量提高一倍后，患者仍保持药物耐受性。
