Lundgren L G, Kindblom L G
Acta Pathol Microbiol Immunol Scand A. 1984 Nov;92(6):401-9.
The clinical picture, the light and electron microscopic appearance, and the histochemical findings are described in six cases of fibroma of tendon sheath. The ages at onset for the four men and two women range between 16 and 54 years. The lesions were well circumscribed, rounded or oval, and had a diameter of about 1 cm. Light-microscopically the lesions consisted of a dense fibrocollagenous tissue with a variable degree of collagenization and cellularity, the peripheral zone often being most cellular and containing slit-like vascular spaces. Electron-microscopically two main cell types were identified: myofibroblasts and fibroblasts, the former dominating in cellular areas, the latter dominating in collagenized areas. The histochemical analysis indicated the presence of sulphated glucosaminoglycans within the collagenous matrix. Immunoperoxidase staining for factor VIII RAG-related antigen gave prominence to the endothelium of capillary-like blood vessels. The differential diagnosis against giant cell tumor of tendon sheath is discussed. The observations indicate that fibroma of tendon sheath is a distinct entity of probable reactive, non-neoplastic nature.
本文描述了6例腱鞘纤维瘤的临床表现、光镜和电镜表现以及组织化学检查结果。4例男性和2例女性的发病年龄在16至54岁之间。病变边界清晰，呈圆形或椭圆形，直径约1cm。光镜下，病变由致密的纤维胶原组织组成，胶原化程度和细胞含量各不相同，周边区域细胞通常最多，并含有裂隙状血管间隙。电镜下鉴定出两种主要细胞类型：肌成纤维细胞和成纤维细胞，前者在细胞区域占主导，后者在胶原化区域占主导。组织化学分析表明在胶原基质中存在硫酸化糖胺聚糖。针对因子VIII RAG相关抗原的免疫过氧化物酶染色突出显示了毛细血管样血管的内皮。文中讨论了与腱鞘巨细胞瘤的鉴别诊断。观察结果表明，腱鞘纤维瘤是一种具有可能的反应性、非肿瘤性质的独特实体。
