Larrègue M, Laidet B, Ramdene P, Djeridi A
Ann Dermatol Venereol. 1984;111(9):789-97.
Five observations of infants with transcutaneous intoxication by 6,3 p. 100 hexachlorophene contaminated talcum powder are reported. The diaper dermatitis is particular because of its topography (red pants shape), of its sudden occurring, of its papyraceous aspect evoking caustic origin, and of its association with severe encephalopathy. The neurological signs start with epileptic fits leading rapidly to coma. Prognosis is serious leading either to death or to paraplegia. Enquiry on that epidemic shows that mortality raised up to 18 p. 100. The neurological signs with oedematous degeneration of myelin are characteristic of hexachlorophene toxicity. Plasma levels of toxics range up to 15,94 mg/ml i.e. 30 times more than the rates observed by Curley in a premature washed with a commercial solution containing 3 p. 100 hexachlorophene. During a toxic neurological syndrome, the existence of diaper dermatitis with red plants shape must lead to an aetiological diagnosis of the possibility of transcutaneous intoxication even if the product seems as harmless as talcum powder.
报告了5例因含6,3%（每100份中含6.3份）六氯酚的滑石粉经皮中毒的婴儿病例。尿布皮炎很特殊，因其形态（红裤状）、突然出现、呈纸样外观提示有腐蚀性来源，以及与严重脑病相关。神经症状始于癫痫发作，迅速发展为昏迷。预后严重，可导致死亡或截瘫。对该流行病的调查显示死亡率高达18%（每100份中含18份）。伴有髓磷脂水肿性变性的神经症状是六氯酚中毒的特征。毒物血浆水平高达15.94毫克/毫升，即比柯利在用含3%（每100份中含3份）六氯酚的商业溶液清洗的早产儿中观察到的水平高30倍。在中毒性神经综合征期间，即使产品看似像滑石粉一样无害，但出现红裤状尿布皮炎时必须进行病因诊断，以确定经皮中毒的可能性。
