Thorel M F, Pardon P, Irgens K, Marly J, Lechopier P
Ann Rech Vet. 1984;15(3):365-74.
The pathogenicity for calves of two strains of wood-pigeon mycobacteria isolated in our laboratory, one strain isolated in the United Kingdom, one strain isolated from a Roe-deer in Denmark and three strains of M. paratuberculosis, were compared. Seven groups of four 3 to 4 week-old calves were infected by the intravenous route using 10(6) to 10(9) viable units. They were slaughtered one year after the exposure or earlier if their state required it. The macroscopic and microscopic lesions and cultures from the mesenteric lymph nodes, ileon and caecum were studied. At necropsy, the post-mortem findings were hardly significant. However, the histopathological studies showed lesions identical to the classical aspects of paratuberculosis in cattle, both in animals inoculated with M. paratuberculosis and those inoculated with wood-pigeon mycobacteria. The isolation of the bacteria showed that all animals were infected. The experimental infection was able to reproduce a disease resembling paratuberculosis with M. paratuberculosis (except the strain 2103) and with wood-pigeon mycobacteria, but it has not been able to distinguish the disease caused by M. paratuberculosis from the one caused by wood-pigeon mycobacteria.
对在我们实验室分离出的两株林鸽分枝杆菌、一株在英国分离出的菌株、一株从丹麦狍子身上分离出的菌株以及三株副结核分枝杆菌对犊牛的致病性进行了比较。七组每组四头3至4周龄的犊牛通过静脉途径感染，使用10(6)至10(9)个活单位。在接触一年后将它们宰杀，若其状况需要则提前宰杀。对肠系膜淋巴结、回肠和盲肠的宏观和微观病变以及培养物进行了研究。尸检时，死后发现几乎没有显著意义。然而，组织病理学研究表明，在接种副结核分枝杆菌的动物和接种林鸽分枝杆菌的动物中，病变均与牛副结核病的经典表现相同。细菌分离表明所有动物均被感染。实验性感染能够用副结核分枝杆菌（2103菌株除外）和林鸽分枝杆菌重现类似副结核病的疾病，但未能区分副结核分枝杆菌引起的疾病和林鸽分枝杆菌引起的疾病。
