Cherniak A Ia, Antonov K V, Dmitriev B A, Kochetkov N K, Padiukov L N
Bioorg Khim. 1984 Oct;10(10):1376-84.
The synthesis of allyl beta-glycoside of cellobiuronic acid by chemical modification of cellobiose was described. The carbohydrate-containing polymers with different content of determinant groups were obtained via radical copolymerization of this hapten with acrylamide. The copolymer which contained 27% carbohydrates and had molecular mass about 100-300 kilodaltons had the serological specificity of the capsular polysaccharide Streptococcus pneumoniae type 3 as shown by an enzyme linked immunosorbent assay.
描述了通过纤维二糖的化学修饰合成纤维二糖醛酸烯丙基β-糖苷的方法。通过该半抗原与丙烯酰胺的自由基共聚反应,获得了具有不同决定簇基团含量的含碳水化合物聚合物。通过酶联免疫吸附测定法表明,含有27%碳水化合物且分子量约为100-300千道尔顿的共聚物具有3型肺炎链球菌荚膜多糖的血清学特异性。