[慢性活动性肝炎中甲状腺激素和促甲状腺激素的行为]

[Behavior of thyroid hormones and TSH in chronic active hepatitis].

作者信息

Licata G, Scaglione R, Dichiara M A, Parrinello G, Capuana G, Di Vincenzo D

出版信息

Boll Soc Ital Biol Sper. 1984 Oct 30;60(10):1863-9.

Abstract

The authors studied total and free circulating thyroid hormones, rT3, TBG and TSH behaviour on chronic liver disease in 11 subjects with cirrhosis of the liver with ascites(C.E.) and in 6 subjects with chronic active hepatitis (E.C.A.) in comparison with 15 healthy and euthyroid controls. Serum T3,FT3,T4 and FT4 levels were decreased significantly and serum rT3 values increased significantly both in the subjects with C.E. and in patients with E.C.A. Moreover no significantly changes of TSH and TBG levels has been found in 3 groups studied. These data suggest that the alteration of circulating thyroid hormones in chronic liver disease, may represent a compensatory way of reducing the patient's metabolic requirements.

摘要

作者研究了11例肝硬化腹水患者（C.E.）和6例慢性活动性肝炎患者（E.C.A.）的总甲状腺激素、游离甲状腺激素、反三碘甲状腺原氨酸（rT3）、甲状腺素结合球蛋白（TBG）和促甲状腺激素（TSH）在慢性肝病中的变化，并与15名健康甲状腺功能正常的对照者进行比较。C.E.患者和E.C.A.患者的血清三碘甲状腺原氨酸（T3）、游离三碘甲状腺原氨酸（FT3）、甲状腺素（T4）和游离甲状腺素（FT4）水平显著降低，血清rT3值显著升高。此外，在研究的3组中未发现TSH和TBG水平有显著变化。这些数据表明，慢性肝病中循环甲状腺激素的改变可能是降低患者代谢需求的一种代偿方式。