具有细胞镶嵌性的小鼠辐射诱导胸腺淋巴瘤的单细胞起源
Single cell origin of radiation-induced thymic lymphoma in mice with cellular mosaicism.
作者信息
Bessho M, Jinnai I, Hirashima K, Tanaka K, Tanooka H
出版信息
Gan. 1984 Nov;75(11):1002-5.
PMID:6519394
Abstract
The clonal origin of radiation-induced thymic lymphoma was studied in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Repeated whole-body X-irradiations (4 doses, 1.7 Gy each) with intervals of 7 days resulted in development of thymic lymphomas in the mosaic mice. PGK from all lymphomas gave only a single spot on electrophoresis. The results demonstrate the single cell origin of the thymic lymphoma.
摘要
利用磷酸甘油酸激酶（PGK）细胞镶嵌的小鼠研究了辐射诱导的胸腺淋巴瘤的克隆起源。对镶嵌小鼠进行重复全身X射线照射（4次剂量，每次1.7 Gy），间隔7天，结果在这些小鼠中诱发了胸腺淋巴瘤。所有淋巴瘤的PGK在电泳时仅出现一个条带。结果证明了胸腺淋巴瘤起源于单个细胞。
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