Take Y, Yamazaki N, Fukuda N, Saji Y, Nagawa Y
Nihon Yakurigaku Zasshi. 1984 Dec;84(6):471-83. doi: 10.1254/fpj.84.471.
We investigated the changes of behavioral, electrophysiological and biochemical parameters during and after global cerebral ischemia in rats. Global cerebral ischemia was produced by the temporary occlusion of both common carotid arteries 24 hr after the permanent electrocauterization of bilateral vertebral arteries. Just before recirculation following 10 or 30 min of cerebral ischemia, loss of righting reflex, flattenning of cortical EEG activity, and detrimental decrease of ATP content and marked increase of lactate content in the cerebrum were observed. The alterations of all parameters completely recovered within 60 min after recirculation in 10-min cerebral ischemic rats. However, the 30-min cerebral ischemic rats showed almost no recovery after recirculation, suggesting that some irreversible damages are produced in the cerebrum of the 30-min ischemic rat. On the other hand, it was found that the auditory brain stem evoked response (ABER) and ATP content in the pons plus medulla were only slightly affected by the ischemic procedure, which indicates that the ischemic damages do not ensue in the lower part of the brain stem.
我们研究了大鼠全脑缺血期间及之后行为、电生理和生化参数的变化。全脑缺血是通过在双侧椎动脉永久性电灼24小时后暂时阻断双侧颈总动脉来产生的。在脑缺血10或30分钟后再灌注前，观察到翻正反射消失、皮层脑电图活动平坦、大脑中ATP含量有害性降低以及乳酸含量显著增加。在10分钟脑缺血大鼠中，再灌注后60分钟内所有参数的改变完全恢复。然而，30分钟脑缺血大鼠再灌注后几乎没有恢复，这表明30分钟缺血大鼠的大脑产生了一些不可逆损伤。另一方面，发现脑桥加延髓中的听觉脑干诱发电位（ABER）和ATP含量仅受到缺血过程的轻微影响，这表明脑干下部未发生缺血损伤。
