Lee S, Cho C K, Kim J G, Chun S I
Int J Dermatol. 1984 Nov;23(9):624-6. doi: 10.1111/j.1365-4362.1984.tb05705.x.
Fifty-nine patients with verrucae (45 with verrucae plana and 14 with verrucae vulgaris) were treated with dinitrochlorobenzene (DNCB) as a topical application on the normal uninvolved skin of the shoulder for sensitization and challenge. The patients were sensitized with 0.5 ml of 0.4% DNCB solution and then challenged with 0.1% DNCB ointment twice a week. Six cases of verrucae plana and 1 case of verrucae vulgaris were completely cured by sensitization only and 32 cases of verrucae plana and 7 cases of verrucae vulgaris were completely resolved by repeated challenges. The therapeutic effect was better in verrucae plana (84.4%) than in verrucae vulgaris (57.1%), and the verrucae were completely resolved within 10 weeks in more than 90% of the patients cured by challenge. The side effects of DNCB were mild allergic contact dermatitis and slight transitory hyperpigmentation at the site of application.
59例疣患者（45例扁平疣和14例寻常疣）接受了二硝基氯苯（DNCB）治疗，将其局部涂抹于肩部正常未受累皮肤进行致敏和激发。患者用0.5毫升0.4%的DNCB溶液进行致敏，然后每周两次用0.1%的DNCB软膏进行激发。6例扁平疣和1例寻常疣仅通过致敏就完全治愈，32例扁平疣和7例寻常疣通过反复激发完全消退。扁平疣的治疗效果（84.4%）优于寻常疣（57.1%），超过90%通过激发治愈的患者的疣在10周内完全消退。DNCB的副作用为应用部位出现轻度过敏性接触性皮炎和轻微短暂性色素沉着。
