Arnup M E, Greville H W, Oppenheimer L, Mink S N, Anthonisen N R
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1569-76. doi: 10.1152/jappl.1984.57.5.1569.
Nine puppies underwent left pneumonectomy at 10 wk of age while nine sex-matched littermates had a sham operation, and all animals were studied at 25 wk of age. Postpneumonectomy dogs demonstrated compensatory growth in that lung weight and total lung capacity (TLC) were the same as those of control animals when normalized for body weight. In postpneumonectomy dogs all lobes of the remaining right lung increased in weight, but this was most notable in the cardiac lobe which grew across the mediastinum. Subdivisions of lung volume were normal in postpneumonectomy animals except for residual volume (RV): RV/TLC was increased when compared with control animals. In intact dogs static pressure-volume curves of the lung and respiratory system did not differ between groups, and the static pressure-volume curves of excised lungs were closely similar. Maximum expiratory flow was sharply reduced in postpneumonectomy dogs, averaging 40% of flow in control dogs over the lower 50% of the vital capacity. In both groups the fractional increase in maximal expiratory flow during HeO2 breathing was substantial and similar. Regional compliances, resistances, and perfusion distribution were examined using 133Xe. Regional compliance and perfusion were reduced in the left hemithorax of postpneumonectomy dogs while regional resistances were increased.
9只幼犬在10周龄时接受了左肺切除术，而9只性别匹配的同窝幼仔接受了假手术，所有动物均在25周龄时进行研究。肺切除术后的犬只表现出代偿性生长，即按体重归一化后，肺重量和总肺容量（TLC）与对照动物相同。在肺切除术后的犬只中，剩余右肺的所有叶重量均增加，但在跨越纵隔生长的心脏叶中最为明显。除残气量（RV）外，肺切除术后动物的肺容积细分正常：与对照动物相比，RV/TLC增加。在完整的犬只中，肺和呼吸系统的静态压力-容积曲线在各组之间没有差异，切除肺的静态压力-容积曲线非常相似。肺切除术后的犬只最大呼气流量急剧降低，在肺活量的下50%范围内平均为对照犬只流量的40%。在两组中，HeO2呼吸期间最大呼气流量的分数增加幅度很大且相似。使用133Xe检查区域顺应性、阻力和灌注分布。肺切除术后犬只左半胸的区域顺应性和灌注降低，而区域阻力增加。
