Jinnai I, Bessho M, Murohashi I, Nara N, Hirashima K
Int J Cell Cloning. 1984 Nov;2(6):341-7. doi: 10.1002/stem.5530020602.
To clarify the relationship between fibroblastoid colony-forming units (CFU-f) and hemopoietic precursor cells, simultaneous assays of CFU-f, CFU-e, BFU-e, and CFU-c from the bone marrow of 10 healthy volunteers were performed. The number of CFU-f correlated positively with CFU-e (r = 0.905, P less than 0.001) and BFU-e (r = 0.842, P less than 0.005), but not with CFU-c (r = 0.530, P greater than 0.1). These findings support the hypothesis that CFU-f is related to erythropoiesis in the steady state of hemopoietic tissue. Further studies of the relationship between CFU-f and erythroid precursor cells in patients with hematological diseases may help clarify their pathophysiology.
为阐明成纤维细胞样集落形成单位（CFU-f）与造血前体细胞之间的关系，对10名健康志愿者骨髓中的CFU-f、CFU-e、BFU-e和CFU-c进行了同步检测。CFU-f的数量与CFU-e（r = 0.905，P < 0.001）和BFU-e（r = 0.842，P < 0.005）呈正相关，但与CFU-c无关（r = 0.530，P > 0.1）。这些发现支持了CFU-f在造血组织稳态中与红细胞生成相关的假说。对血液系统疾病患者中CFU-f与红系前体细胞之间关系的进一步研究可能有助于阐明其病理生理学。
