Marzo A, Ghirardi P, Lorenzi G, Marini A
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):73-6. doi: 10.1007/BF00586600.
Deslanatoside C-3H was injected (i.p. 50 microgram/kg) into rabbits of 1, 4, 10, 20 days and more than 1 year old. The rabbits were sacrificed 2 and 6 h after dosing. Levels in all tissues were higher in newborn rabbits, decreased in the older animals and then in most tissues increased in adults to different degrees, showing the highest values in kidneys. Biliary excretion and above all urinary excretion increased with age. Levels in atria, ventricles, aorta and liver in rabbits 1 and 4 days old were consistently higher at the 6th h than those at the 2nd h, these tissues showing a particularly marked avidity with Deslanatoside C; in the older animals this behaviour was reversed. These data and those of other Authors working on other glycosides (incleding Digoxin) and other species (including newborn children) lead to the conclusion that digitalis glycosides in new born species are excreted at a lower rate and incorporated in the body tissues at a higher rate than in adults. They may also in part explain the large dosages employed in human infants in comparison with adults, as the higher distribtuion volume retains a large amount of the injected glycoside.
将去乙酰毛花苷C-3H（腹腔注射，剂量为50微克/千克）注射到1日龄、4日龄、10日龄、20日龄及1岁以上的兔子体内。给药后2小时和6小时处死兔子。新生兔所有组织中的药物水平较高，随着年龄增长在年长动物中降低，然后在大多数组织中成年动物又不同程度升高，在肾脏中达到最高值。胆汁排泄尤其是尿液排泄随年龄增加。1日龄和4日龄兔子心房、心室、主动脉和肝脏中的药物水平在6小时时始终高于2小时时，这些组织对去乙酰毛花苷C表现出特别明显的亲和力；在年长动物中这种情况则相反。这些数据以及其他研究其他糖苷（包括地高辛）和其他物种（包括新生儿）的作者的数据得出结论，新生物种中洋地黄糖苷的排泄率低于成年动物，而在体内组织中的摄取率高于成年动物。这也可以部分解释与成年人相比人类婴儿使用大剂量药物的原因，因为更高的分布容积会保留大量注射的糖苷。
