Craighill M C, Cramer D W
J Reprod Med. 1984 Nov;29(11):784-7.
The epidemiology of complete molar pregnancy is dominated by two strong factors. The first is the wide geographic variation in incidence, from less than 1 per 1,000 deliveries in the United States and Canada to about 1 per 100 deliveries in Indonesia and other Asian countries. The second factor is maternal age, with an increasing risk of molar pregnancy with increasing maternal age. Both genetic and environmental factors may underlie these two risk factors. The genetic factors may include chromosomal defects that occur as a consequence of oocyte aging. The environmental factors probably include nutrition. Although many aspects of nutrition deserve further study, some new research suggests that a focus on vitamin A metabolism may be especially profitable.
完全性葡萄胎的流行病学主要受两个重要因素影响。第一个因素是发病率在地理上差异很大，在美国和加拿大每1000次分娩中不到1例，而在印度尼西亚和其他亚洲国家约为每100次分娩1例。第二个因素是母亲年龄，随着母亲年龄的增加，葡萄胎妊娠的风险也在增加。这两个风险因素可能都有遗传和环境因素作为基础。遗传因素可能包括由于卵母细胞老化而出现的染色体缺陷。环境因素可能包括营养。尽管营养的许多方面都值得进一步研究，但一些新的研究表明，关注维生素A代谢可能会特别有成效。
