Rabin B M, Miller D S, Ievoli R J
Neuroendocrinology. 1978;25(3):129-40. doi: 10.1159/000122735.
The role of gonadal hormones in modulating the hypothalamic multi-unit activity (MUA) response to glucose and saline was studied in normal and gonadectomized male and female rats. In intact male rats, unlike intact females, all hypothalamic placements showed either an increase or a decrease in MUA following an injection of glucose. Gonadectomy alone did not produce a significant change in the pattern of hypothalamic response to glucose. Daily injections of estradiol-17beta resulted in a significant increase in the number of hypothalamic sites that did not show a glucose-induced change in MUA. In general, the effects on saline tended to parallel those on glucose, although the changes were not as extensive. The results are discussed of estradiol modulation of body weight (b.w.) and of the hypothalamic responsiveness to various stimuli, including glucosse and saline injections.
在正常及去性腺的雄性和雌性大鼠中，研究了性腺激素在调节下丘脑对葡萄糖和生理盐水的多单位活动（MUA）反应中的作用。在完整的雄性大鼠中，与完整的雌性大鼠不同，注射葡萄糖后，所有下丘脑部位的MUA要么增加，要么减少。单独去性腺并未使下丘脑对葡萄糖的反应模式产生显著变化。每日注射17β-雌二醇导致未出现葡萄糖诱导的MUA变化的下丘脑部位数量显著增加。一般来说，对生理盐水的影响往往与对葡萄糖的影响相似，尽管变化没有那么广泛。讨论了雌二醇对体重（b.w.）以及下丘脑对包括葡萄糖和生理盐水注射在内的各种刺激的反应性的调节作用。
