Kunieda T, Kawata R, Nayashi K, Nishiwaki T, Kunieda K, Saji S, Sakata K
Nihon Geka Gakkai Zasshi. 1984 Nov;85(11):1472-8.
Biochemical, histological and CT examinations of the liver were performed in 32 rabbits on significance of measuring CT values in the diagnosis of fatty liver. In 2 groups of rabbits, in which 2g/kg/day and 4g/kg/day of fat emulsion were administered intravenously for 4 weeks respectively, post-treatment reduction in CT value of light degree was observed. In a group, in which 8g/kg/day were given, there was a sufficient reduction in CT value for giving diagnosis of fatty liver of moderate degree. Significant correlation was found between changes in CT value of the liver on the one hand and contents of triglyceride, total cholesterol and cholesterol ester in the liver on the other hand, while there was, no significant correlation between changes in CT value and contents of phospholipid, protein and water. Significant correlation was found between changes in CT value of the liver and degrees of histological fat accumulation in the liver cells. It has been evidenced experimentally that prolonged administration of fat emulsion may cause fatty liver, and that measurement of CT values of the liver is a non-aggressive method of diagnosing fatty liver.
对32只兔子进行了肝脏的生化、组织学和CT检查，以研究测量CT值在脂肪肝诊断中的意义。在两组兔子中，分别静脉注射2g/kg/天和4g/kg/天的脂肪乳剂，持续4周，治疗后观察到轻度CT值降低。在给予8g/kg/天的一组中，CT值有足够的降低，可诊断为中度脂肪肝。一方面，肝脏CT值的变化与肝脏中甘油三酯、总胆固醇和胆固醇酯的含量之间存在显著相关性，而CT值的变化与磷脂、蛋白质和水的含量之间没有显著相关性。肝脏CT值的变化与肝细胞组织学脂肪堆积程度之间存在显著相关性。实验证明，长期给予脂肪乳剂可能导致脂肪肝，并且测量肝脏CT值是一种非侵入性的脂肪肝诊断方法。
