Sokolova I S, Elekes I, Otvös L, Gorbacheva L B
Neoplasma. 1984;31(6):667-73.
The rates of incorporation of 2-14C-thymidine into DNA of melanoma B16, bone marrow, gastrointestinal mucosa, spleen and liver at various time after administration of dianhydrogalactitol (DAG), 3,4-diacetyldianhydrogalactitol (DiacDAG) and 3,4-disuccinyldianhydrogalactitol (DisuDAG) at maxima nonlethal single doses to tumor-bearing mice were studied. The sugar alcohol derivatives induced the stable inhibition in DNA synthesis of tumor cells. DNA synthesis in normal dividing cells was shown to recover more rapidly than in melanoma B16 cells after administration of all drugs. DisuDAG is characterized by stronger inhibitory effect on DNA synthesis in melanoma B16 cells at the half of the single maxima nonlethal dose compared with DAG and DiacDAG. Differing from DAG, DiacDAG and DisuDAG did not effect the incorporation of 2-14C-thymidine into DNA of liver cells. In vivo inhibition of DNA synthesis in melanoma B16 cells with DiacDAG was not due to damage of the TCA soluble fraction.
研究了在给荷瘤小鼠单次给予最大非致死剂量的双脱水半乳糖醇（DAG）、3,4-二乙酰双脱水半乳糖醇（DiacDAG）和3,4-二琥珀酰双脱水半乳糖醇（DisuDAG）后，不同时间点2-¹⁴C-胸苷掺入黑色素瘤B16、骨髓、胃肠道黏膜、脾脏和肝脏DNA中的速率。糖醇衍生物诱导肿瘤细胞DNA合成产生稳定抑制。在给予所有药物后，正常分裂细胞中的DNA合成显示比黑色素瘤B16细胞恢复得更快。与DAG和DiacDAG相比，DisuDAG在单次最大非致死剂量的一半时对黑色素瘤B16细胞的DNA合成具有更强的抑制作用。与DAG不同，DiacDAG和DisuDAG不影响2-¹⁴C-胸苷掺入肝细胞的DNA。DiacDAG对黑色素瘤B16细胞DNA合成的体内抑制并非由于三羧酸循环可溶性部分的损伤。
