Gottardi E, Di Marco G
Minerva Med. 1984 Nov 30;75(45-46):2733-9.
65 heroin addicts who had previously underwent liver biopsy for liver disease were studied retrospectively; the histological features of liver disease and hepatitis B serological markers were analyzed in detail. Alcohol abuse was rare in this group (6.1%), but moderate or occasional use of mild alcoholic beverages was common. The liver biopsy examination showed that 35 (54%) had chronic active hepatitis, 21 (32%) had non specific reactive hepatitis, 6 (9%) had acute hepatitis and 3 (5%) had chronic persistent hepatitis. Steatosis was present in 41% of all biopsies. 19 subjects were HBsAg positive, and in 60 (92.3%) at least one marker of HBV was found. Observation of liver biopsy specimen under polarized light did not disclose the presence of birefringent material consistent with talc or other inorganic material. These results suggest that HBV infection is responsible for liver disease in heroin addicts in the great majority of cases.
对65名曾因肝脏疾病接受肝活检的海洛因成瘾者进行了回顾性研究；详细分析了肝脏疾病的组织学特征和乙肝血清学标志物。该组中酒精滥用情况罕见（6.1%），但适度或偶尔饮用轻度酒精饮料较为常见。肝活检检查显示，35例（54%）患有慢性活动性肝炎，21例（32%）患有非特异性反应性肝炎，6例（9%）患有急性肝炎，3例（5%）患有慢性持续性肝炎。所有活检中有41%存在脂肪变性。19名受试者HBsAg呈阳性，60例（92.3%）至少发现一种HBV标志物。在偏光下观察肝活检标本未发现与滑石粉或其他无机物质一致的双折射物质。这些结果表明，在绝大多数情况下，HBV感染是海洛因成瘾者肝脏疾病的病因。
