Zapata P, Torrealba F
Neurosci Lett. 1984 Oct 26;51(3):359-64. doi: 10.1016/0304-3940(84)90403-8.
The sensory discharges from the carotid body chemoreceptors of the cat are transiently inhibited by dopamine (DA) injections. This chemosensory inhibition was effectively blocked by domperidone, a selective antagonist of D2 dopaminoceptors. The basal frequency of spontaneous chemosensory impulses was immediately and sustainly increased after domperidone, suggesting the withdrawal of a tonic inhibition of chemosensory discharges by endogenous DA released from glomus cells. The peripheral dopaminergic modulation of chemoreflexes may be separately blocked by domperidone, a drug unable to cross the blood-brain barrier.
给猫的颈动脉体化学感受器注射多巴胺（DA）会使其感觉放电受到短暂抑制。这种化学感觉抑制可被多潘立酮有效阻断，多潘立酮是D2多巴胺受体的选择性拮抗剂。注射多潘立酮后，化学感觉自发冲动的基础频率立即且持续增加，这表明球细胞释放的内源性DA对化学感觉放电的紧张性抑制作用被解除。多潘立酮是一种无法穿过血脑屏障的药物，它可能会单独阻断化学反射的外周多巴胺能调节。
