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清醒猴子被动手部运动的小脑反馈信号

Cerebellar feedback signals of a passive hand movement in the awake monkey.

作者信息

Bauswein E, Kolb F P, Rubia F J

出版信息

Pflugers Arch. 1984 Nov;402(3):292-9. doi: 10.1007/BF00585512.

DOI:10.1007/BF00585512
PMID:6522240
Abstract

From three intact and awake monkeys, 149 Purkinje cells and 44 presumed mossy fibres were recorded in the intermediate part of the cerebellar anterior lobe, and this activity was analyzed with regard to different parameters of a passive hand movement. The tonic discharge rate of the simple spikes (SS) varied according to different joint positions only in a single Purkinje cell, whereas such a position relation was found in nine out of 44 presumed mossy fibres. A phasic increase of the complex spike (CS) discharge rate of Purkinje cells in response to passive wrist movements usually occurred within 100 ms after movement onset. However, in some units a phase of increased CS rate was observed which lasted for the whole movement duration. The amount of this phasic increase in the CS rate depended on the acceleration of movement, but the SS response to movements of different velocity remained unchanged.

摘要

从三只完整且清醒的猴子身上,在小脑前叶中间部分记录了149个浦肯野细胞和44条推测的苔藓纤维,并针对被动手部运动的不同参数对该活动进行了分析。简单锋电位(SS)的紧张性放电率仅在单个浦肯野细胞中随不同关节位置而变化,而在44条推测的苔藓纤维中有九条发现了这种位置关系。浦肯野细胞复合锋电位(CS)放电率在被动腕部运动时的相位增加通常在运动开始后100毫秒内出现。然而,在一些单位中观察到CS率增加的阶段持续了整个运动持续时间。CS率这种相位增加的量取决于运动的加速度,但SS对不同速度运动的反应保持不变。

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本文引用的文献

1
Information about peripheral events conveyed to the cerebellum via the climbing fiber system in the decerebrate cat.在去大脑猫中,通过攀缘纤维系统传递至小脑的关于外周事件的信息。
Exp Brain Res. 1980;38(4):363-73. doi: 10.1007/BF00237516.
2
Patterns of activity evoked in cerebellar interpositus nuclear neurones by natural somatosensory stimuli in awake cats.清醒猫中自然体感刺激诱发小脑间位核神经元的活动模式。
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Simple and complex spike activity of cerebellar Purkinje cells during active and passive movements in the awake monkey.
正常受试者和小脑受损受试者传入反应的起始时间以及用于运动控制的动觉信息的使用情况。
Exp Brain Res. 1997 Jan;113(1):33-47. doi: 10.1007/BF02454140.
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Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.缺乏代谢型谷氨酸受体mGluR4亚型的小鼠中,小脑突触可塑性和运动表现受损。
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Characteristics of posture alterations associated with a stepping movement in cats.猫步行动作相关姿势改变的特征
Exp Brain Res. 1994;98(2):287-97. doi: 10.1007/BF00228416.
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Cerebellar unit responses of the mossy fibre system to passive movements in the decerebrate cat. I. Responses to static parameters.去大脑猫苔藓纤维系统对被动运动的小脑单位反应。I. 对静态参数的反应。
Exp Brain Res. 1987;68(2):234-48. doi: 10.1007/BF00248790.
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Comparative analysis of cerebellar unit discharge patterns in the decerebrate cat during passive movements.去大脑猫在被动运动期间小脑单位放电模式的比较分析。
Exp Brain Res. 1987;68(2):219-33. doi: 10.1007/BF00248789.
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J Physiol. 1983 Jun;339:379-94. doi: 10.1113/jphysiol.1983.sp014722.
4
Simple-spike activity of cerebellar Purkinje cells related to visually guided wrist tracking movement in the monkey.与猴子视觉引导的手腕跟踪运动相关的小脑浦肯野细胞的简单锋电位活动。
J Neurophysiol. 1980 Mar;43(3):713-28. doi: 10.1152/jn.1980.43.3.713.
5
A simple method for reliable separation of cerebellar Purkinje cell complex and simple spikes.
Pflugers Arch. 1983 Sep;398(4):341-3. doi: 10.1007/BF00657245.
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Somatosensory receptive fields of single units in cat cerebellar cortex.猫小脑皮质单个神经元的躯体感觉感受野
J Neurophysiol. 1967 Jul;30(4):675-96. doi: 10.1152/jn.1967.30.4.675.
7
Discharge of cerebellar neurons related to two maintained postures and two prompt movements. II. Purkinje cell output and input.与两种维持姿势和两种快速运动相关的小脑神经元放电。II. 浦肯野细胞的输出与输入。
J Neurophysiol. 1970 Jul;33(4):537-47. doi: 10.1152/jn.1970.33.4.537.
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Discharge of cerebellar neurons related to two maintained postures and two prompt movements. I. Nuclear cell output.与两种维持姿势和两种快速运动相关的小脑神经元放电。I. 核细胞输出。
J Neurophysiol. 1970 Jul;33(4):527-36. doi: 10.1152/jn.1970.33.4.527.
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Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. I. In mossy fibers and granule cells.肢体神经的传入冲动影响小脑皮质的冲动发放。I. 苔藓纤维和颗粒细胞。
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J Physiol. 1974 Mar;237(2):371-84. doi: 10.1113/jphysiol.1974.sp010486.