Shimizu M, Yoneda S, Miura K, Miyoshi H, Watanabe K
Nucleic Acids Symp Ser. 1984(15):193-6.
Strong and specific interactions between amino acids and their cognate tRNAs have been found by the CD, fluorescence, and UV absorption difference spectroscopy and by the gel-filtration method. New types of strong hydrogen bonding interactions between an amino acid and polynucleotides, nucleotides, nucleosides, and nucleic acid bases in aqueous solution have also been detected. These findings are strong experimental evidence for the C4N model of the genetic code. The cases of glutamate and aspartate will theoretically be discussed in details.
