脱氧核糖核苷-3',5'-环硅二烷基衍生物：形成与性质
Deoxyribonucleoside-3',5'-cyclic silanediyl derivatives: formation and properties.
作者信息
Furusawa K, Katsura T, Sakai T, Tsuda K
出版信息
Nucleic Acids Symp Ser. 1984(15):41-4.
PMID:6522290
Abstract
Formation of 3',5'-O-(dialkylsilanediyl)deoxyribonucleosides was studied. Treatment of deoxythymidine in DMF with bifunctional silylating reagent such as di-t-butyldichlorosilane and diisopropyldichlorosilane in the presence of imidazole gave the expected silanediyl derivatives. The structure was confirmed mainly by NMR spectroscopy. The stability of these cyclic silyl derivatives toward hydrolysis is also described.
摘要
对3'，5'-O-（二烷基硅撑）脱氧核糖核苷的形成进行了研究。在咪唑存在下，用双官能硅烷化试剂如二叔丁基二氯硅烷和二异丙基二氯硅烷在N，N-二甲基甲酰胺中处理脱氧胸苷，得到了预期的硅撑衍生物。结构主要通过核磁共振光谱进行确证。还描述了这些环状硅衍生物对水解的稳定性。
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