Fava G A, Michelacci L, Trombini G, Bovicelli L, Orlandi C
Prenat Diagn. 1984 Nov-Dec;4(6):397-404. doi: 10.1002/pd.1970040602.
Twenty woman at risk of carrying a fetus with homozygous beta-thalassemia who underwent fetoscopy and a matched control group of pregnant women were administered the Symptom Questionnaire to evaluate changes in distress. Women who were offered fetoscopy had significantly more anxiety, depression, somatic symptoms and hostility than the control group. Psychological distress significantly decreased after the results of fetoscopy were communicated to the patient, and the decrease was similar in normal control women. Five other patients had a diagnosis of homozygous beta-thalassaemia and their pregnancies were terminated. Their psychological distress increased when they learned the outcome of fetoscopy, but decreased again after termination. Psychological reactions to fetoscopy and amniocentesis appear to be similar, yet women who undergo fetoscopy suffer from more psychological distress.
对20名有携带纯合子β地中海贫血胎儿风险且接受了胎儿镜检查的女性以及一组匹配的孕妇对照组进行了症状问卷调查，以评估痛苦程度的变化。接受胎儿镜检查的女性比对照组有明显更多的焦虑、抑郁、躯体症状和敌意。在将胎儿镜检查结果告知患者后，心理痛苦显著减轻，正常对照组女性的减轻程度相似。另外5名患者被诊断为纯合子β地中海贫血，她们的妊娠被终止。当她们得知胎儿镜检查结果时，心理痛苦增加，但在终止妊娠后又再次减轻。对胎儿镜检查和羊膜穿刺术的心理反应似乎相似，但接受胎儿镜检查的女性遭受更多的心理痛苦。
