Pelle C, Berruchon J, Plessis F, Caron-Poitreau C, George P
Rev Mal Respir. 1984;1(5):295-9.
This study concerns 45 patients operated on for a primary bronchial cancer and without local or regional extension on a standard pulmonary radiograph. All subjects had a computed tomographic examination (TDM) on average 28 days before thoracotomy. The comparison was established and the possibility of excising the tumour, joined to an anatomopathological study of the structures removed. The series included only those patients with the following minimal conditions: tumour volume of 4 cms, central tumour, or close to the chest wall. The degree of pleural extension was predicted with a sensibility of 92%, a specificity of 72% (accuracy of 78%). The parietal extension was predicted with a sensibility of 63%, a specificity of 100% (accuracy of 95%). Direct invasion of the mediastinum, present 16 times, was recognized by the scanner in 8 occasions (sensibility 50%) and excluded 23 times out of 25 (specificity 85%). Extension to mediastinal ganglions was detected by the scanner 10 times out of 15; the absence of invasion 27 times out of 30. Thus, if sometimes the TDM examination showed the certainty of local or regional tumour extension, in many cases it did not by itself allow this conclusion. This was true for tumours flush with the pleura or mediastinum because their resolution was insufficient to distinguish neoplastic tissue from normal or inflammatory tissue. The TDM always established a remarkable "map" of the mediastinal glands guiding the biopsy or the thoracotomy in case of enlarged glands. One of the limits includes the possibility of occult extension without glandular hypertrophy.
本研究涉及45例接受原发性支气管癌手术且标准胸部X线片显示无局部或区域扩散的患者。所有受试者在开胸手术前平均28天进行了计算机断层扫描(CT)检查。进行了对比,并结合切除肿瘤的可能性以及对切除结构的解剖病理学研究。该系列仅包括满足以下最低条件的患者:肿瘤体积为4厘米、中央型肿瘤或靠近胸壁。预测胸膜侵犯程度的敏感度为92%,特异度为72%(准确率为78%)。预测壁层侵犯的敏感度为63%,特异度为100%(准确率为95%)。纵隔直接侵犯出现16次,CT扫描识别出8次(敏感度50%),25次中有23次排除(特异度85%)。CT扫描在15次中有10次检测到纵隔淋巴结转移;30次中有27次未发现侵犯。因此,有时CT检查显示局部或区域肿瘤扩散确定,但在许多情况下,仅凭CT检查本身无法得出这一结论。对于与胸膜或纵隔平齐的肿瘤来说确实如此,因为其分辨率不足以区分肿瘤组织与正常或炎性组织。CT总能建立一张出色的纵隔淋巴结“图谱”,在淋巴结肿大时指导活检或开胸手术。其中一个局限性包括存在无淋巴结肿大的隐匿性扩散的可能性。