Anniko M, Wróblewski R
Scan Electron Microsc. 1984(Pt 4):2067-75.
Freeze-fracture studies on the inner ear have been focused mainly on the normal structure of junctions sealing the endolymphatic compartment, the compartmentalization of the stria vascularis and the junctional stability of the hair cells towards adjacent supporting cells. The hair cells have a very tight type of zonulae occludenetes as compared with other non-sensory epithelia in the inner ear. In contrast to other epithelial cells, the mature hair cells are in most species lacking gap junctions. During embryonic development a loss of gap junctions is an early and significant feature of cells differentiating into future hair cells. The tight junctions in the secretory epithelia (stria vascularis in the cochlea and dark cells around vestibular organs) are morphologically mature before the onset of the ionic maturation of endolymph. Freeze-fracture studies on inner ear pathology are few. The structural alterations of tight junctions in the diseased inner ear are minimal. The functional significance of such small morphological derangements is not known.
内耳的冷冻断裂研究主要集中在封闭内淋巴腔室的连接结构的正常结构、血管纹的分隔以及毛细胞与相邻支持细胞之间的连接稳定性。与内耳其他非感觉上皮相比，毛细胞具有一种非常紧密的紧密连接类型。与其他上皮细胞不同，大多数物种的成熟毛细胞缺乏间隙连接。在胚胎发育过程中，间隙连接的丧失是细胞分化为未来毛细胞的早期且显著的特征。分泌上皮（耳蜗中的血管纹和前庭器官周围的暗细胞）中的紧密连接在淋巴离子成熟开始之前在形态上就已成熟。关于内耳病理学的冷冻断裂研究很少。患病内耳中紧密连接的结构改变很小。这种微小形态紊乱的功能意义尚不清楚。
