雌激素α-亚甲基-δ-内酯的合成及其细胞毒性活性
Synthesis and cytotoxic activity of estrogen alpha-methylene-delta-lactones.
作者信息
Chagonda L S, Lockey P M, Marples B A, Traynor J R
出版信息
Steroids. 1984 Mar;43(3):283-92. doi: 10.1016/0039-128x(84)90046-1.
PMID:6523545
Abstract
Several estrogen derivatives containing the alpha-methylene-delta-lactone group as part of the D-ring were prepared as anti-tumor agents. The compounds were highly toxic towards HeLa S3 cells grown in culture.
摘要
制备了几种含有α-亚甲基-δ-内酯基团作为D环一部分的雌激素衍生物作为抗肿瘤剂。这些化合物对培养的HeLa S3细胞具有高度毒性。
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