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[Characteristics of hepatocyte proliferation in the regenerating rat liver with hydroxyurea synchronization of the proliferative processes].

作者信息

Osipova L A, Zatsarnaia A P, Khranovskaia L N, Bykorez A I

出版信息

Tsitologiia. 1984 Nov;26(11):1278-82.

PMID:6523573
Abstract

5-week old rats underwent a partial hepatectomy (2/3 of the liver was removed). The operated rats were repeatedly injected hydroxyurea, within 9-24 or 12-24 hours following operation. Proliferation of hepatocytes and non-parenchymal cells in the regenerating liver was studied. Five or six injections of hydroxyurea increased the labelling index of hepatocytes up to 62.5% and induced proliferation of bile duct cells significantly.

摘要

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