[对紫外线敏感的中国仓鼠克隆细胞中咖啡因依赖性复制后DNA修复缺陷]
[Defect in the caffeine-dependent postreplication DNA repair in UV-sensitive Chinese hamster clone cells].
作者信息
Tavartkiladze B A, Pinto R I, Zhestianikov V D
出版信息
Tsitologiia. 1984 Nov;26(11):1295-301.
The postreplication repair of DNA in the presence of caffeine was investigated in the Chinese hamster clones cells of different UV-sensitivity. Caffeine (10(-2)M) inhibits the repair of daughter DNA (PRR of DNA) in the UV-light irradiated cells of UV-resistant clones CHO-K1, 14-2C-1 and V79, but does not influence the PRR of DNA in cells of UV-sensitive clones CHS1 and CHS2. Thus, deficiency of PRR of DNA in cells of UV-sensitive clones (the repair of daughter DNA is significantly retarded) is associated with the defect of the caffeine-dependent component of this repair process.
在不同紫外线敏感性的中国仓鼠克隆细胞中研究了咖啡因存在下DNA的复制后修复。咖啡因（10^(-2)M）抑制紫外线抗性克隆CHO-K1、14-2C-1和V79的紫外线照射细胞中子代DNA的修复（DNA的PRR），但不影响紫外线敏感克隆CHS1和CHS2细胞中DNA的PRR。因此，紫外线敏感克隆细胞中DNA的PRR缺陷（子代DNA的修复显著延迟）与该修复过程中咖啡因依赖性成分的缺陷有关。
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