Khan S R, Finlayson B, Thomas W C, Hackett R L
Urol Res. 1984;12(6):271-3. doi: 10.1007/BF00258033.
Calcium oxalate crystalluria was induced in laboratory rats by subcutaneous implantation of potassium oxalate containing mini-osmotic pumps in their intercapsular region. Concentrations of major urinary ions were measured and urinary supersaturations of various urinary salts were calculated using a computer programme. The urines of experimental animals that received oxalate had calcium oxalate crystals and higher supersaturations for calcium oxalate compared to their controls. Oxalate levels of the urines of experimental animals were higher than their controls and this increase was proportional to the increase in urinary supersaturation of calcium oxalate. No significant difference was found in the calcium levels of urines from experimental and control animals.
通过在实验大鼠的囊间区域皮下植入含草酸钾的微型渗透泵，诱导大鼠出现草酸钙结晶尿。测量主要尿离子的浓度，并使用计算机程序计算各种尿盐的尿过饱和度。与对照组相比，接受草酸盐的实验动物尿液中有草酸钙晶体，且草酸钙的过饱和度更高。实验动物尿液中的草酸盐水平高于对照组，且这种增加与草酸钙尿过饱和度的增加成正比。实验动物和对照动物尿液中的钙水平没有显著差异。
