Garbuzov A G, Medvedev F A, Levachev M M
Vopr Pitan. 1984 Nov-Dec(6):54-6.
The results of experiments on rats given the ergosterol-containing diet for a long time indicate that ergosterol was incorporated in liver tissues in trace amounts which are not comparable with ergosterol concentrations exerting an effect in model experiments. Ergosterol was not detected in the liver after 3-day experiments. At the same time it was established that the proportion of unchanged ergosterol in rat feces was about 16% of the amount administered per os. The products of a possible ergosterol transformation (dehydroneoergosterol-24-methyl-1,3,5 (10), 6,8 (9), 22-hexaen-3 beta-ol; 24-methylcholesta-7,24 (28)-dien-3 beta-ol; 4-cholesta-7,22,25 (?)-trien-3 beta-ol; 4-methylcholesta-7,22 (?)-dien-3 beta-ol, and so forth were identified in feces.
长期给大鼠喂食含麦角固醇的饮食的实验结果表明，麦角固醇以痕量形式掺入肝脏组织，这与在模型实验中发挥作用的麦角固醇浓度不可比。3天实验后在肝脏中未检测到麦角固醇。同时确定，大鼠粪便中未变化的麦角固醇比例约为经口给予量的16%。在粪便中鉴定出了可能的麦角固醇转化产物（脱氢新麦角固醇-24-甲基-1,3,5(10),6,8(9),22-六烯-3β-醇；24-甲基胆甾-7,24(28)-二烯-3β-醇；4-胆甾-7,22,25(?) -三烯-3β-醇；4-甲基胆甾-7,22(?) -二烯-3β-醇等）。
