Shalkovskaia L N, Losev N A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1984 Nov-Dec;34(6):1066-71.
In chronic experiments on cats with unilateral ablations of the motor cortical area, recovery of motor function of the contralateral forelimb was observed in average on the 31-th day after ablation. Stimulation of M-cholinoreactive brain biosystems by galantamine in combination with simultaneous suppression of N-cholinoreactive biosystems by ganglerone, shortened the period of complete compesation up to 10 days. Suppression of M-cholinoreactive systems and simultaneous stimulation of N-cholinoreactive ones by metamisil combined with galantamine prolonged the recovery period up to several months. A conclusion is drawn of an important role of M- and N-cholinergic mechanisms in providing compensatory possibilities of the brain.
在对单侧运动皮层区域进行切除的猫的慢性实验中，平均在切除后第31天观察到对侧前肢运动功能的恢复。加兰他敏刺激M-胆碱能反应性脑生物系统，同时用甘罗溴铵抑制N-胆碱能反应性生物系统，可将完全代偿期缩短至10天。美他西泮联合加兰他敏抑制M-胆碱能反应性系统并同时刺激N-胆碱能反应性系统，可将恢复期延长至数月。得出结论：M-和N-胆碱能机制在提供大脑代偿可能性方面具有重要作用。
