Balle V H, Bretlau P, Hainau B
Acta Otolaryngol. 1984 Nov-Dec;98(5-6):413-7. doi: 10.3109/00016488409107582.
Skin biopsies taken from patients with osteogenesis imperfecta tarda and otosclerosis were compared blind by light- and electron microscopy with similar biopsies taken from normal volunteers in an effort to find common pathological features in the collagen fibres from the two patient groups, thus corroborating the theory that osteogenesis imperfecta and otosclerosis might be due to a common genetic anomaly in the form of a mesenchymal hypoplasia. We were not able to find differences in structure or quantity of the collagen-, elastic- or reticular fibres between normals and the two patient groups. We cannot, on the basis of our previous work and on the present morphological investigation, give support to the above-mentioned theory.
对迟发性成骨不全症和耳硬化症患者的皮肤活检样本与正常志愿者的类似活检样本进行了盲法比较，通过光学显微镜和电子显微镜观察，试图找出两组患者胶原纤维的共同病理特征，从而证实成骨不全症和耳硬化症可能是由于间充质发育不全这种常见遗传异常导致的理论。我们未能发现正常人与两组患者之间在胶原纤维、弹性纤维或网状纤维的结构或数量上存在差异。基于我们之前的研究工作以及当前的形态学调查，我们无法支持上述理论。
