Rosén C, Christensen P, Hovelius B, Prellner K
Acta Otolaryngol. 1984 Nov-Dec;98(5-6):524-32. doi: 10.3109/00016488409107593.
A long-term study of nasopharyngeal carriership in 405 children, aged 6 months to 5 years, attending day-care centres was performed. The effect of pneumococcal vaccination was evaluated in a double-blind investigation where the children received either Pneumovax (a 14-valent pneumococcal vaccine) or saline. Nasopharyngeal cultures were taken monthly by a trained nurse during a 2-year follow-up period. No difference in pneumococcal carriage was found between vaccinees and controls. Pneumococci were found in 31.9% of all cultures. In day-care centres attended by greater than or equal to 45 children the carriage rate of pneumococci was significantly higher than in centres with less than 45 children. Spreading of pneumococci within day-care centres was common but rather short-lived. Children younger than 2 years showed the highest carriage rates. Pneumococci of group 6 were carried most frequently and for longer periods than groups 19 and 23.
对405名年龄在6个月至5岁、参加日托中心的儿童进行了一项关于鼻咽带菌情况的长期研究。在一项双盲调查中评估了肺炎球菌疫苗接种的效果，在该调查中，儿童分别接种了Pneumovax（一种14价肺炎球菌疫苗）或生理盐水。在为期2年的随访期间，由一名经过培训的护士每月采集鼻咽培养物。在接种疫苗者和对照组之间未发现肺炎球菌携带情况的差异。在所有培养物中，31.9%检测到肺炎球菌。在儿童人数大于或等于45名的日托中心，肺炎球菌的携带率显著高于儿童人数少于45名的中心。肺炎球菌在日托中心内的传播很常见，但持续时间较短。2岁以下儿童的携带率最高。6组肺炎球菌的携带最为频繁，且携带时间比19组和23组更长。
