Lörelius L E, Stridbeck H
Acta Radiol Diagn (Stockh). 1984;25(6):529-33.
VX2 tumors in the rabbit hind leg were investigated at one, two and three weeks of age. Angiograms were compared with vascular casts. The tumors grew rapidly the first two weeks of age. Large variations in vascularity were noted between tumors of different ages. With increasing age arteriovenous shunts at the tumor periphery and areas of avascularity or necrosis in the tumor center increased in size. Possible reasons for tumor necrosis are increased tissue pressure, anoxia caused by arteriovenous shunts and elevation in venous pressure. The natural history of the VX2 tumor must be considered in every experimental study of the effect of any treatment.
对兔后肢VX2肿瘤在1周、2周和3周龄时进行了研究。将血管造影与血管铸型进行了比较。肿瘤在出生后的前两周生长迅速。不同年龄的肿瘤之间血管分布存在很大差异。随着年龄的增长，肿瘤周边的动静脉分流以及肿瘤中心的无血管或坏死区域的大小增加。肿瘤坏死的可能原因是组织压力增加、动静脉分流导致的缺氧以及静脉压升高。在任何治疗效果的实验研究中，都必须考虑VX2肿瘤的自然病程。
