豚鼠心脏各部位H1受体的存在：结合研究与功能研究之间的相关性
On the presence of H1-receptors in various sections of guinea-pig heart: a correlation between binding and functional studies.
作者信息
Bennardini F, Amerini S, Franconi F, Ledda F, Mantelli L, Matucci R, Mugelli A, Sorbi C
出版信息
Agents Actions. 1984 Oct;15(3-4):167-71. doi: 10.1007/BF01972344.
PMID:6524516
Abstract
The binding of 3H-mepyramine in different sections of guinea-pig heart was examined. 3H-mepyramine binds to a single class of binding sites to guinea-pig ventricular membranes and to right atrial suspension with an apparent dissociation constant (Kd) of 4.35 nM and 14.90 nM respectively. When treated as those obtained from the right atrium, the left atrial suspensions do not seem to bind 3H-mepyramine specifically.
摘要
研究了3H-美吡拉敏在豚鼠心脏不同部位的结合情况。3H-美吡拉敏与豚鼠心室膜及右心房悬液中的一类结合位点结合，其表观解离常数（Kd）分别为4.35 nM和14.90 nM。当将左心房悬液按照从右心房获得的样本进行处理时，似乎不会特异性结合3H-美吡拉敏。
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