Moukhtar M S
Biomed Pharmacother. 1984;38(5):257-60.
The principal problems related to the radioimmunoassay of calcitonin are discussed: the low circulating concentrations of the hormone in normal subjects; the heterogeneity of the circulating and tissular forms of the molecule; the diversity of the antibodies used and the restricted size of the antigenic site; the divergence between the biological and immunological domains. These findings have little incidence on the measurement of the hormonal concentration in subjects suffering either from medullary carcinoma of the thyroid or tumours producing the hormone ectopically. In contrast, determining the circulating levels of calcitonin in cases of eu- or hypocalcitonism are more problematic in view of the problems reported.
正常受试者中该激素的循环浓度较低；分子的循环形式和组织形式存在异质性；所用抗体的多样性以及抗原位点的大小受限；生物学和免疫学领域之间的差异。这些发现对患有甲状腺髓样癌或异位产生该激素的肿瘤患者的激素浓度测量影响较小。相比之下，鉴于所报告的问题，在正常降钙素血症或低降钙素血症病例中测定降钙素的循环水平则更具问题。
