Vandenbroucke J P
Biomed Pharmacother. 1984;38(8):379-81.
The paper firstly reviews the recent epidemiological literature on the apparently protective effect of oral contraceptive use on the onset of rheumatoid arthritis. This epidemiological evidence is then placed in the wider context of both old and recent clinical observations on the influence of pregnancy, the menstrual cycle and exogeneous sex hormones on the course of rheumatoid arthritis. Finally, possible hints for underlying biological mechanisms are discussed.
本文首先回顾了近期关于口服避孕药对类风湿关节炎发病具有明显保护作用的流行病学文献。然后,将这一流行病学证据置于关于妊娠、月经周期和外源性性激素对类风湿关节炎病程影响的新旧临床观察的更广泛背景中。最后,讨论了潜在生物学机制的可能线索。