Chandler S H, Goldberg L J
Brain Res. 1984 Dec 10;323(2):297-301. doi: 10.1016/0006-8993(84)90301-9.
The central pattern generator (CPG) for rhythmical jaw movements (RJMs) was activated, in the anesthetized guinea pig, by systemic injection of a specific dopamine agonist, apomorphine (APO). It was shown that APO induced RJMs required an intact superior colliculus, and were blocked by low doses (0.05-1.0 mg/kg) of haloperidol (HAL), a dopamine antagonist. This is in contrast to the neural pathways mediating RJMs evoked by repetitive electrical stimulation of the masticatory cortex which remained effective following both lesions of the superior colliculus and administration of HAL. These results suggest that there are at least two anatomically separate and pharmacologically distinct command centers for activation of the CPG for RJMs in the guinea pig.
在麻醉的豚鼠中，通过全身注射特定的多巴胺激动剂阿扑吗啡（APO），可激活用于节律性下颌运动（RJM）的中枢模式发生器（CPG）。结果表明，APO诱导的RJM需要完整的上丘，并且会被低剂量（0.05 - 1.0毫克/千克）的多巴胺拮抗剂氟哌啶醇（HAL）阻断。这与介导由咀嚼皮层重复电刺激诱发的RJM的神经通路形成对比，后者在上丘损伤和给予HAL后仍保持有效。这些结果表明，在豚鼠中，至少存在两个在解剖学上相互独立且在药理学上不同的指令中心，用于激活RJM的CPG。
