Manca C, Dei Cas L, Bernardini B, Barilli A L, Tsialtas D, Vasini P, Visioli O
Cardiology. 1984;71(6):341-7. doi: 10.1159/000173688.
In order to evaluate both quantitatively and qualitatively exercise ST response in females, we have studied 232 healthy subjects (age range 35-59 years): 82 women (mean age 45.8 years) and 150 men (mean age 46.1 years). All subjects had performed a maximal treadmill exercise in 1976 and were followed up for 6 years in order to exclude the presence of subclinical coronary artery disease. Exercise ST segment responses were evaluated in a single bipolar lead (CB5) and were classified as 'positive' by visual interpretation when a 1.0-mm or greater 'ischemic' ST depression occurred. A computer system was employed to evaluate exercise ST changes quantitatively. The following ST parameters were evaluated: ST depression at R + 80 ms point (ST2); mean ST depression (STmean), and ST time-voltage integral (STarea). Computer analysis of resting ECG has shown lower ST voltages in females than in males. ST2, STarea, and STmean changes from basal to maximal exercise values were not significantly different in men and women. A similar prevalence of 'positive' responses in males and females was also found by ECG visual interpretation. In conclusion, our data show that in healthy subjects exercise ST segment response is comparable in males and females and indirectly suggest that the lower predictive value of exercise ECG in women is likely to be related to different coronary artery disease prevalence.
为了从定量和定性两方面评估女性运动时的ST段反应，我们研究了232名健康受试者（年龄范围35 - 59岁）：82名女性（平均年龄45.8岁）和150名男性（平均年龄46.1岁）。所有受试者在1976年都进行了一次最大运动平板试验，并随访6年以排除亚临床冠状动脉疾病的存在。运动ST段反应在单极双导联（CB5）中进行评估，当出现1.0毫米或更大的“缺血性”ST段压低时，通过视觉解读将其分类为“阳性”。使用计算机系统对运动时的ST段变化进行定量评估。评估了以下ST段参数：R + 80毫秒点的ST段压低（ST2）、平均ST段压低（STmean）和ST段时间 - 电压积分（STarea）。静息心电图的计算机分析显示，女性的ST段电压低于男性。男性和女性从基础运动到最大运动时ST2、STarea和STmean的变化无显著差异。通过心电图视觉解读还发现男性和女性“阳性”反应的发生率相似。总之，我们的数据表明，在健康受试者中，男性和女性的运动ST段反应具有可比性，并且间接表明女性运动心电图较低的预测价值可能与不同的冠状动脉疾病患病率有关。
