Sordillo L M, Oliver S P, Duby R T, Rufner R
Int J Biochem. 1984;16(11):1135-41. doi: 10.1016/0020-711x(84)90006-5.
Intramammary colchicine infusion into goats at parturition reduced milk yield by 20% during the 30 day experimental period. During the first week of lactation, milk composition from colchicine-treated udder halves had elevated somatic cell numbers, serum albumin concentration and pH, while citrate concentration was lower in comparison to uninfused glands. Levels of lactose from both infused and uninfused udder halves were normal during the first week of lactation. No differences were observed in degree of alveolar development in tissue samples collected prior to treatment. Light and electron microscopy suggested that colchicine-treated udder halves consisted predominantly of undifferentiated mammary secretory cells, while uninfused udder halves appeared more cytologically differentiated. Results demonstrated that intramammary colchicine infusion at parturition temporarily altered milk composition and inhibited mammary cellular differentiation.
分娩时向山羊乳房内注入秋水仙碱，在30天的实验期内，产奶量降低了20%。在泌乳的第一周，用秋水仙碱处理过的乳房半边所产牛奶的体细胞数量、血清白蛋白浓度和pH值升高，而与未注入的腺体相比，柠檬酸盐浓度较低。在泌乳的第一周，注入和未注入秋水仙碱的乳房半边所产乳糖水平均正常。在治疗前采集的组织样本中，未观察到肺泡发育程度的差异。光学显微镜和电子显微镜检查表明，用秋水仙碱处理过的乳房半边主要由未分化的乳腺分泌细胞组成，而未注入秋水仙碱的乳房半边在细胞学上似乎分化程度更高。结果表明，分娩时向乳房内注入秋水仙碱会暂时改变牛奶成分并抑制乳腺细胞分化。
