Harris D P, Sinclair J G
Gen Pharmacol. 1984;15(6):449-54. doi: 10.1016/0306-3623(84)90198-8.
Single unit cerebellar Purkinje cell activity was recorded extracellularly in urethane-anaesthetised rats. An inhibition of these cells, believed to be GABA-mediated, which is produced by local surface stimulation of the cerebellar cortex was antagonized by the local, micropressure application of ethanol. The inhibition of cerebellar Purkinje cells produced by local micropressure application of GABA was similarly antagonized by a slow i.v. infusion of ethanol (1.5 g/kg over 10 min). When both ethanol and GABA were applied to the Purkinje cells by local micropressure the results were difficult to interpret due to an ethanol-induced decrease in the baseline firing rate. There was a decrease in the absolute GABA-mediated inhibition but no change in the relative inhibition. In general, it appears that ethanol produces an antagonism of GABA-mediated inhibition of cerebellar Purkinje cells.
在氨基甲酸乙酯麻醉的大鼠中，细胞外记录单个单位的小脑浦肯野细胞活动。这些细胞的抑制作用被认为是由γ-氨基丁酸（GABA）介导的，通过对小脑皮质进行局部表面刺激产生，而通过局部微量注射乙醇可对抗这种抑制作用。通过缓慢静脉输注乙醇（10分钟内输注1.5克/千克），同样可对抗由局部微量注射GABA所产生的小脑浦肯野细胞的抑制作用。当通过局部微量注射将乙醇和GABA都应用于浦肯野细胞时，由于乙醇导致基线放电率降低，结果难以解释。绝对的GABA介导的抑制作用有所降低，但相对抑制作用没有变化。总体而言，乙醇似乎对GABA介导的小脑浦肯野细胞抑制作用产生拮抗作用。
