Aronson C E, West R C, Spear J F
Gen Pharmacol. 1984;15(6):523-8. doi: 10.1016/0306-3623(84)90209-x.
Chlorpromazine altered the mechanical and electrical activity of the isolated perfused guinea pig heart. While its effects on coronary flow were variable, chlorpromazine increased resting diastolic isometric tension and decreased the isometric systolic tension developed by spontaneously beating hearts. Heart rate was also decreased. The drug depressed conduction through the His-Purkinje system and ventricular muscle to a greater extent than it did atrial conduction time and AV nodal conduction time. From our data, we concluded that the greatest depressant action of chlorpromazine on the electrical activity of the isolated perfused guinea pig heart occurred within the specialized ventricular conduction system and ventricular muscle.
氯丙嗪改变了离体灌注豚鼠心脏的机械和电活动。虽然其对冠脉血流的影响不一，但氯丙嗪增加了静息舒张期等长张力，并降低了自发搏动心脏产生的等长收缩期张力。心率也降低了。该药物对希氏 - 浦肯野系统和心室肌传导的抑制作用，比对心房传导时间和房室结传导时间的抑制作用更大。根据我们的数据，我们得出结论，氯丙嗪对离体灌注豚鼠心脏电活动的最大抑制作用发生在特殊的心室传导系统和心室肌内。
