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红细胞δ-氨基乙酰丙酸脱水酶的免疫学和酶学研究。正常受试者与铅暴露受试者所得结果的比较。

Immunological and enzymatic studies of erythrocytic delta-aminolevulinate dehydratase. Comparison of results obtained in normal and lead-exposed subjects.

作者信息

Boudene C, Despaux-Pages N, Comoy E, Bohuon C

出版信息

Int Arch Occup Environ Health. 1984;55(1):87-96. doi: 10.1007/BF00378071.

DOI:10.1007/BF00378071
PMID:6526504
Abstract

The delta-aminolevulinate dehydratase (ALA.D) quantitative assay on a centrifugal fast analyser showed that subjects whose blood-lead level varies between 30 and 75 micrograms/100 ml (1.5 to 3.75 microM/l) react to blood intoxication by synthesizing de novo an amount of enzyme correlating to blood-lead levels. At higher concentrations, the reactional synthesis occurs very rarely. These results suggest that enzyme is constitutive, but also inductible as soon as its substrate accumulates; this last ability may disappear at high blood-lead levels: a hypothesis is proposed thereafter.

摘要

在离心式快速分析仪上进行的δ-氨基乙酰丙酸脱水酶（ALA.D）定量测定表明，血铅水平在30至75微克/100毫升（1.5至3.75微摩尔/升）之间变化的受试者，会通过重新合成一定量与血铅水平相关的酶来应对血液中毒。在更高浓度时，反应性合成很少发生。这些结果表明，该酶是组成型的，但一旦其底物积累就可诱导合成；后一种能力可能在高血铅水平时消失：此后提出了一个假设。

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1
Immunological and enzymatic studies of erythrocytic delta-aminolevulinate dehydratase. Comparison of results obtained in normal and lead-exposed subjects.红细胞δ-氨基乙酰丙酸脱水酶的免疫学和酶学研究。正常受试者与铅暴露受试者所得结果的比较。
Int Arch Occup Environ Health. 1984;55(1):87-96. doi: 10.1007/BF00378071.
2
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Clin Biochem. 1971 Dec;4(4):222-32. doi: 10.1016/s0009-9120(71)91692-4.
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Delta aminolevulinic acid dehydratase amounts in lead-exposed subjects: description of a method correlated with the immunoturbidimetric assay.铅暴露受试者体内的δ-氨基乙酰丙酸脱水酶含量：一种与免疫比浊法相关的方法的描述

本文引用的文献

1
Zinc and cysteine residues in the active site of bovine liver delta-aminolevulinic acid dehydratase.
Int J Biochem. 1980;12(5-6):751-6. doi: 10.1016/0020-711x(80)90157-3.
2
Evidence of increased synthesis of delta-aminolevulinic acid dehydratase in experimental lead-poisoned rats.实验性铅中毒大鼠中δ-氨基乙酰丙酸脱水酶合成增加的证据。
Biochim Biophys Acta. 1981 Nov 18;678(1):39-50. doi: 10.1016/0304-4165(81)90045-3.
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Restoration of lead-inhibited 5-aminolevulinate dehydratase activity in whole blood by heat, zinc ion, and (or) dithiothreitol.通过加热、锌离子和（或）二硫苏糖醇恢复全血中铅抑制的5-氨基乙酰丙酸脱水酶活性。
Int Arch Occup Environ Health. 1986;57(4):303-13. doi: 10.1007/BF00406185.
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Evaluation of a new specific analysis of urinary delta-aminolevulinic acid in man.
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Increase in the amount of erythrocyte delta-aminolevulinic acid dehydratase in workers with moderate lead exposure.中度铅暴露工人红细胞δ-氨基乙酰丙酸脱水酶含量增加。
Int Arch Occup Environ Health. 1982;50(3):287-97. doi: 10.1007/BF00378090.
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[Delta-aminolevulinate dehydratase activity of erythrocytes as a diagnostic test in occupational lead poisoning].[红细胞δ-氨基乙酰丙酸脱水酶活性作为职业性铅中毒诊断试验的研究]
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[Allosteric regulation of erythrocyte delta-aminolevulinic dhydratase activity].[红细胞δ-氨基乙酰丙酸脱水酶活性的变构调节]
Boll Soc Ital Biol Sper. 1968 Apr 15;44(7):692-5.
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Delta-aminolevulinic acid dehydratase activity in erythrocytes for the evaluation of lead poisoning.用于评估铅中毒的红细胞中δ-氨基乙酰丙酸脱水酶活性
Clin Chim Acta. 1968 Feb;19(2):319-25. doi: 10.1016/0009-8981(68)90341-0.
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Delta-aminolevulinic acid dehydrase as a measure of lead exposure.δ-氨基乙酰丙酸脱水酶作为铅暴露的一种衡量指标。
Arch Environ Health. 1970 Aug;21(2):140-5. doi: 10.1080/00039896.1970.10667211.
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[Influence of the heat on erythrocyte ALA-dehydratase activity in the rabbit and man. I. Findings in lead poisoning].[热对家兔和人体红细胞δ-氨基-γ-酮戊酸脱水酶活性的影响。I.铅中毒的研究结果]
Lav Um. 1971 Jan;23(1):1-10.
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Symptomatic porphyria I. The effects of lead on the synthesis of porphyrin and haem.症状性卟啉病I. 铅对卟啉和血红素合成的影响
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