Vaziri N D, Toohey J, Paule P, Alikhani S, Hung E
Int J Artif Organs. 1984 Nov;7(6):323-6.
Plasma levels of various blood coagulation factors, antithrombin III and plasminogen were measured in 18 patients with end-stage renal disease treated by longterm hemodialysis. The results were compared with those obtained in a group of normal volunteers. Factors XII, IX and II activities were significantly reduced; factors VIII, VII and X levels were increased; and factors XI and V activities and high molecular weight kininogen concentration were comparable to the control group. Antithrombin III activity and concentration were significantly reduced. The mean plasma fibrinogen concentration was normal although levels above and below normal limits were noted in a few patients. Similarly the mean platelet count was normal, although mild thrombocytopenia occurred in several patients and thrombocytosis in one. In conclusion, the present study confirms published results about factor VIII and AT-III, and provides new information on changes of other coagulation factors in uremia treated by long-term hemodialysis.
对18例接受长期血液透析治疗的终末期肾病患者的各种血液凝固因子、抗凝血酶III和纤溶酶原的血浆水平进行了测定。将结果与一组正常志愿者的结果进行了比较。因子XII、IX和II的活性显著降低；因子VIII、VII和X的水平升高；因子XI和V的活性以及高分子量激肽原浓度与对照组相当。抗凝血酶III的活性和浓度显著降低。尽管在少数患者中观察到纤维蛋白原水平高于或低于正常范围，但血浆纤维蛋白原平均浓度正常。同样，血小板平均计数正常，尽管有几名患者出现轻度血小板减少，一名患者出现血小板增多。总之，本研究证实了关于因子VIII和抗凝血酶III的已发表结果，并提供了长期血液透析治疗的尿毒症患者其他凝血因子变化的新信息。
