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[冷适应对遗传性肥胖 Zucker 大鼠摄食行为的影响]

[Effect of cold adaptation on the feeding behavior of genetically obese Zucker rats].

作者信息

Bertin R, De Marco F, Portet R

出版信息

J Physiol (Paris). 1984;79(5):361-4.

PMID:6527285
Abstract

A diurnal hyperphagia is certainly the main factor of adiposity in the genetically obese Zucker fa/fa rat. In a previous experiment it was observed that cold-acclimatization suppressed hyperphagia and stopped the increase in obesity. In this work, the chronology of modification in the feeding pattern is studied during the first month of cold exposure (10 degrees C). The main cold-induced modifications are observed after 2 weeks of cold exposure. Possibly the decrease in metabolic efficiency of food could parallel the cold-induced enhancement of energetic capacity of brown adipose tissue which has been described elsewhere. This tissue could play a role in the obesity of the Zucker rat.

摘要

昼夜过度摄食无疑是遗传性肥胖的Zucker fa/fa大鼠肥胖的主要因素。在先前的一项实验中观察到,冷适应可抑制过度摄食并阻止肥胖的增加。在这项研究中,研究了在冷暴露(10摄氏度)的第一个月期间进食模式改变的时间顺序。主要的冷诱导变化在冷暴露2周后观察到。食物代谢效率的下降可能与冷诱导的棕色脂肪组织能量容量增强同时发生,这在其他地方已有描述。该组织可能在Zucker大鼠的肥胖中起作用。

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